Guest is incompatible with the Restricted Autonomy setting for this reason (and vice-versa-they will turn each other off). The exception to this is Guest, which simply enables the Thrall, if an NPC, to act like an invited Guest in your home.
Most roles are a particular high priority (ex: Maid has a high priority to clean). It's up to you and you can change it on a given sim at any time. Roles can be activated at the same time, allowing you to combine them for creative use.
